Its long been known that the administration of oral or injectible steroids like dexamethasone could cause complications in horses with Cushings. This study shows that steroids in topical creams can be absorbed through the skin, causing measurable amounts to show up blood samples.
"We were really surprised to see such massive systemic changes in such a short time," Abraham said. "And this was in healthy horses.
The study, "Effects of dermal dexamethasone application on ACTH and both basal and ACTH-stimulated cortisol concentration in normal horses," was published in the August 2009 Journal of Veterinary Pharmacology and Therapeutics.
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